Conferencia magistral | Broadening our genomic knowledge of the human microbiome

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Expositor internacional

  • Dr. Robert Finn (EMBL-EBI, Cambridge, Reino Unido)

Tema:  (Exposición en Inglés)  Broadening our genomic knowledge of the human microbiome

Sumilla

The human body is host to trillions of microbes, collectively referred to as the human microbiome, which have adapted to a range of environments, such as the gut, oral cavity and skin. A variety of factors can affect microbial imbalance, which has a close relationship with human health and disease. Metagenomics, the analysis of the sum of genetic material from a sample, is shedding light on the huge diversity of micro-organisms that occupy these different environments provided by the human host. Last year witnessed three large, independent collections of published metagenome assembled genomes (MAGs) from the human gut microbiome were amalgamated yielding over 200,000 non-redundant MAGs, to produce the Unified Human Gastrointestinal Genome (UHGG) collection. Analysis of UHGG has revealed that a large portion of the human gut microbiome remains to be fully explored, with over 70% of the UHGG species lacking cultured representatives, and 40% of the proteins they encode lacking meaningful functional annotations. As new datasets from under-represented populations emerge, the number of novel species (not represented in the UHGG thus far) remains surprisingly low, highlighting the breadth of the UHGG collection. Nevertheless, there is a fundamental need to broaden research into the human microbiome to encompass all populations.

Moderadora

  • Dra. Layla Hirsh

Expositores

Organizado por

  • Vicerrectorado de Investigación PUCP